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BBS5 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549330

Catalog No. PA549330

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Predicted to react with monkey and mouse based on sequence homology.

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
Specifications

Specifications

BBS5
Polyclonal
PBS with 0.09% sodium azide
Q8N3I7
Bardet-Biedl syndrome 5 protein, BBS5
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
129880
Western Blot
Unconjugated
BBS5
Liquid
BBS5
KLH conjugated synthetic peptide between 108-141 amino acids from the Central region of human BBS5.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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