Bcl-10 Mouse anti-Human, Alexa Fluor™ 750, Clone: BL10/411, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP233190AF750

Catalog No. NP233190A70

Description

Bcl-10 Monoclonal specifically detects Bcl-10 in Human samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

• Antigen: Bcl-10
• Classification: Monoclonal
• Conjugate: Alexa Fluor 750
• Formulation: 50 mM sodium borate with 0.05% sodium azide
• Gene Symbols: BCL10
• Immunogen: Human Bcl-10 recombinant protein (epitope aa122-168) (Uniprot: O95999)
• Quantity: 0.1 mL
• Primary or Secondary: Primary
• Test Specificity: BCL10, with an N-terminal caspase recruitment domain (CARD), is found in a number of apoptotic regulatory molecules. It was identified through its direct involvement in t(1;14) of mucosa-associated lymphoid tissue (MALT) lymphoma. Expression of BCL10 was shown to induce NFKB activation in a NIK-dependent pathway. This MAb labels subpopulations of normal B and T cells and is a useful tool for the sub-classification of lymphomas. In MALT lymphomas with the t(1;14) translocation, while 55% of MALT lymphomas lacking this translocation exhibited the same labeling pattern, although at a much lower level.
• Content And Storage: Store at 4°C in the dark.

• Applications: ELISA
• Clone: BL10/411
• Dilution: ELISA
• Gene Alias: B-cell CLL/lymphoma 10CIPERCLAPB-cell lymphoma/leukemia 10, Bcl-10, CARD-containing apoptotic signaling protein, CARD-containing molecule enhancing NF-kappa-B, CARD-containing proapoptotic protein, CARD-like apoptotic protein, CARMEN, caspase-recruiting domain-containing protein, cCARMEN, c-E10bcl-10, CED-3/ICH-1 prodomain homologous E10-like regulator, Cellular homolog of vCARMEN, cellular-E10, hCLAP, Mammalian CARD-containing adapter molecule E10, mE10CARD containing molecule enhancing NF-kB
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Research Discipline: Apoptosis, Cancer
• Gene ID (Entrez): 8915.0
• Target Species: Human
• Isotype: IgG1 κ