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Bcl-2 Mouse anti-Human, Porcine, Primate, Mouse, Rat, Alexa Fluor 594, Clone: 8C8, Novus Biologicals
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP233313AF594
DescriptionBcl-2 Monoclonal antibody specifically detects Bcl-2 in Human, Porcine, Primate, Mouse, Rat samples. It is validated for Western Blot, ELISA, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen).
|Western Blot, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen|
|A synthetic peptide corresponding to amino acids 41-60 of human Bcl-2 was used as immunogen to generate the antibody; GenBank no. NP_000648.2. This sequence is 100% conserved in the human alpha (239 aa) and beta (205 aa) isoforms.|
|Protein A or G purified|
|Apoptosis, Autophagy, Biologically Active Proteins, Cancer, Cellular Markers, Mitochondrial Mediated Pathway, Mitophagy, Oncogenes, Phospho Specific, Tumor Suppressors|
|Human, Mouse, Porcine, Primate, Rat|
|ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot|
|Alexa Fluor™ 594|
|50 mM sodium borate with 0.05% sodium azide|
|apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, Bcl-2|
|Store at 4°C in the dark.|
|This antibody recognizes a protein of 25-26kDa, identified as the bcl-2 alpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2 alpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.|
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