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Bcl-2 Mouse anti-Human, Mouse, Rat, Alexa Fluor™ 594, Clone: 100/D5, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus BiologicalsSupplier Diversity Partner NBP233315AF594

Catalog No. NP23331A94


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Description

Description

Bcl-2 Monoclonal antibody specifically detects Bcl-2 in Human,Mouse,Rat samples. It is validated for Western Blot,ELISA,Immunohistochemistry,Immunocytochemistry,Immunofluorescence,Immunohistochemistry (Paraffin),Immunohistochemistry (Frozen).
Specifications

Specifications

Bcl-2
100/D5
Western Blot, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen
apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, Bcl-2
Mouse
IgG1 Kappa
Store at 4°C in the dark.
Monoclonal
This antibody recognizes a protein of 25-26kDa, identified as the bcl-2alpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2alpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2alpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.
ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot
Alexa Fluor™ 594
50 mM sodium borate with 0.05% sodium azide
BCL2
The synthetic peptide corresponding to amino acids range from 41-64 (GAAPAPGIFSSQPG-Cys), of human Bcl-2 was used as immunogen to generate the antibody; GenBank no. NP_000648.2 (Pezzella et al, 1990).
0.1 mL
Primary
596
Human, Mouse, Rat
Documents
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