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Bcl-2 Mouse anti-Human, PE, Clone: 100, Invitrogen™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MHBCL04

Catalog No. 50-112-1296


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Description

Description

R-phycoerythrin (PE) is a stable and highly soluble phycobiliprotein which provides maximal absorbance and fluorescence without susceptibility to internal or external fluorescence quenching, thus providing an exceptional quantum yields and molar extinction coefficients.

BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the anti-apoptotic effect of BCL-2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends. The overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.
Specifications

Specifications

Bcl-2
Monoclonal
PE
BCL2
Liquid
BCL2
Human B cell leukemia/lymphoma 2 (Bcl-2) antigen
Purified
ASR
Antibody
Monoclonal
Human
Flow Cytometry
100
PBS with 4mg/mL BSA, sucrose and 0.1% sodium azide
P10415
PPP1R50, apoptosis regulator Bcl-2, protein phosphatase 1 regulatory subunit 50
Mouse
IgG1
0.5 mL
4° C, store in dark
Primary
596
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