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Bcl-2 Mouse anti-Mouse, Rat, PE, Clone: 10C4, eBioscience™ Invitrogen™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

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Catalog No. 12-699-241


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Description

Description

The 10C4 monoclonal antibody reacts with mouse and rat Bcl-2, also known as B cell lymphoma 2. Bcl-2 is the founding member of the Bcl-2 family of evolutionarily-conserved proteins that regulate cell death/survival. Members of the Bcl-2 family include the pro-apoptotic proteins BAD, Bax, and Bim, and the anti-apoptotic proteins Bcl-2, Bcl-xL, and Mcl-1. Bcl-2 inhibits apoptosis by preventing the release of cytochrome c from the mitochondria. Mutation of Bcl-2 or overexpression of Bcl-2 due to chromosomal translocation has been identified as a contributing factor in numerous cancers. In developing thymocytes, Bcl-2 is expressed at high levels in CD4-CD8- double negative and in CD4+ and CD8+ single positive thymocytes; Bcl-2 expression is greatly diminished in CD4+CD8+ double positive thymocytes. Applications Reported: This 10C4 antibody has been reported for use in intracellular staining followed by flow cytometric analysis. Applications Tested: This 10C4 antibody has been pre-diluted and tested by intracellular staining followed by flow cytometric analysis of mouse thymocytes. This may be used at 5 μL (0.25 μg) per test. A test is defined as the amount ( μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser

Bcl-2 Monoclonal antibody specifically detects Bcl-2 in Mouse, Rat samples. It is validated for Flow Cytometry
Specifications

Specifications

Bcl-2
Flow Cytometry
10C4
PE
Bcl2
Apoptosis regulator Bcl-2; AW986256; B cell leukemia/lymphoma 2; B cell lymphoma 2 associated oncogene; B-cell CLL/lymphoma 2; B-cell leukemia/lymphoma 2; Bcl 2; BCL2; bcl-2; BCL2 apoptosis regulator; BCL2, apoptosis regulator; Bcl2-like protein; C430015F12Rik; D630044D05Rik; D830018M01Rik; OTTHUMP00000163680; PPP1R50; protein phosphatase 1, regulatory subunit 50
IgG1, kappa
25 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
12043, 24224
Liquid
Monoclonal
5 μL/Test
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
P10417, P49950
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse, Rat
SDS
Documents
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