Bcl-6, Mouse anti-Human, Alexa Fluor 532, Clone: BCL6/1982, Novus Biologicals™
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP275749AF532
DescriptionBcl-6 Monoclonal antibody specifically detects Bcl-6 in Human samples. It is validated for ELISA, Immunohistochemistry, Immunohistochemistry (Paraffin).
|ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin|
|50mM Sodium Borate with 0.05% Sodium Azide|
|Recombinant human Bcl-6 protein fragment (around aa256-389) (exact sequence is proprietary)|
|Protein A or G purified|
|Store at 4°C in the dark.|
|Recognizes a protein of 95 kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large ( L&H ) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.|
|Alexa Fluor 532|
|B-cell CLL/lymphoma 6, B-cell lymphoma 6 protein transcript, BCL-5, BCL5B-cell lymphoma 5 protein, BCL-6, BCL6A, cys-his2 zinc finger transcription factor, LAZ3ZBTB27B-cell lymphoma 6 protein, lymphoma-associated zinc finger gene on chromosome 3, Protein LAZ-3, Zinc finger and BTB domain-containing protein 27, Zinc finger protein 51ZNF51, zinc finger transcription factor BCL6S|
|Cancer, Cell Cycle and Replication, Tumor Suppressors|
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