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BCL6 Mouse anti-Human, Mouse, Clone: GI191E, eBioscience™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

$129.00 - $305.00

Specifications

Antigen BCL6
Clone GI191E
Target Species Human, Mouse
Conjugate Unconjugated
Isotype IgG1, kappa
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-138-24 Non-distribution product as customer accommodation.
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Invitrogen
14988780
25 μg Each for $129.00
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50-138-25 Non-distribution product as customer accommodation.
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Invitrogen
14988782
100 μg Each for $305.00
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Description

Description

Description: This GI191E monoclonal antibody reacts with mouse and human Bcl-6, which is also known as B-cell lymphoma 6. A member of the POZ family of transcriptional repressors, Bcl-6 is expressed most abundantly in germinal center B cells, as well as in differentiating and activated B cells. This 79-kDa protein is essential for germinal center B cell proliferation and survival. Moreover, during B cell development, Bcl-6 plays an important role in promoting pre-B cell survival to enable the generation of a diverse B cell repertoire. Moreover, Bcl-6 is expressed constitutively in diffuse large B cell lymphomas (DLBCLs), Burkitt ft.s lymphoma, and non-Hodgkin ft.s lymphoma. Reports also suggest expression of Bcl-6 in CD4+ T follicular helper cells and memory T cells. Bcl-6 has been reported to be antagonized by Blimp-1. Applications Reported: This GI191E antibody has been reported for use in immunoblotting (WB) and immunohistochemistry (FFPE). Applications Tested: This GI191E antibody has been tested by immunoblotting of reduced cell lysate prepared from A20 cells and by immunohistochemistry on human tissue using high pH antigen retrieval. This antibody can be used at less than or equal to 5 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.

2 µm post-manufacturing filtered. Bcl-6 proto-oncogene product (a Kruppel-type zinc-finger protein) is mainly expressed in normal germinal center B cells and related lymphomas. Bcl-6 is involved in chromosome rearrangements at 3q27 in non-Hodgkin ft.s lymphomas and Bcl-6 rearrangements have been detected in 33%-45% of diffuse large B cell lymphomas. Bcl-6 has been detected immunohistochemically in follicular lymphomas, diffuse large B cell lymphomas, Burkitt ft.s lymphomas and in nodular, lymphocyte predomit Hodgkin ft.s disease.
Specifications

Specifications

BCL6
Human, Mouse
IgG1, kappa
Monoclonal
Liquid
Antibody
4° C
GI191E
Unconjugated
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Primary
Monoclonal
PBS with 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.

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