BCL2L1 Mouse anti-Human, Clone: OTI2D1, liquid, TrueMAB™ 

Mouse Monoclonal Antibody

Manufacturer:  OriGene TA506188

Catalog No. 50-167-6528

Description

The protein encoded the BCL-X gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.

Specifications

• Antigen: BCL2L1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q07817
• Gene Alias: BCL-XL/S, BCL2L, BCLX, Bcl-X, PPP1R52
• Host Species: Mouse
• Isotype: IgG1
• Quantity: 100 μL
• Storage Requirements: -20° C, Avoid Freeze/Thaw Cycles
• Primary or Secondary: Primary
• Gene ID (Entrez): 598

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI2D1
• Conjugate: Unconjugated
• Gene: BCL2L1
• Format: Liquid
• Gene Symbols: BCL2L1
• Immunogen: Full length human recombit protein of human BCL2L1 produced in HEK293T cell.
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Monoclonal
• Target Species: Human