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BCL9L Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA561946

Catalog No. PIPA561946


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Description

Description

Immunogen sequence: MSMCHPGQMS LLGRTGVPPQ QGMVPHGLHQ GVMSPPQGLM TQQNFMLMKQ RGVGGEVYSQ PPHMLSPQGS LMGPPPQQNL MVSHPLRQRS VSLDSQMGYL PAP Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 97%.

Bcl9L, a homolog of Bcl9, was initially identified through a bioinformatics screening. It is expressed in fetal brain, adult lung, eye and prostate, in addition to several types of tumors including pancreatic and prostate cancers. Bcl9L has been shown to interact with beta-catenin, a target of the Wnt signaling pathway, and is required for enhanced beta-catenin-T-cell factor (TCF)-mediated transcription in colorectal tumor cells, possibly by translocating beta-catenin to the nucleus. Other studies have indicated that Bcl9L expression correlates with high nuclear grade cancer phenotype and the expression of ErbB2/HER-2 in breast cancers, suggesting that activity may occur in other types of cancer. Bcl9L has also been shown to be critical for Wnt-mediate regulation of stem cell traits in colon epithelium and adenocarcinomas which are associated with tumor invasion, metastasis, and resistance to therapy.
Specifications

Specifications

BCL9L
Polyclonal
Unconjugated
BCL9L
Liquid
BCL9L
Recombit protein corresponding to Human BCL9L
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
0.1 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Q86UU0
BCL9-2, DLNB11; B-cell CLL/lymphoma 9-like protein; B-cell lymphoma 9-like protein; BCL9-like protein; nuclear co-factor of beta-catenin signalling; protein BCL9-2
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
283149
Documents
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