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BCOR Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550919

Catalog No. PA550919


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Description

Description

BCOR Polyclonal Antibody detects endogenous levels of BCOR protein.

Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3  ft.Lys-4 ft. (H3K4me3) and  ft.Lys-36 ft. (H3K36me2). {ECO:0000269; PubMed:10898795, ECO:0000269; PubMed:15004558, ECO:0000269; PubMed:18280243, ECO:0000269; PubMed:19578371, ECO:0000269; PubMed:23911289}.
Specifications

Specifications

BCOR
Polyclonal
Unconjugated
BCOR
Liquid
BCOR
Synthesized peptide derived from the Internal region of human BCoR.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
ELISA, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
Q6W2J9, Q8CGN4
KIAA1575
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
54880, 71458
Documents
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