BCR Rabbit anti-Human, Non-human primate, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 225851AP
DescriptionA reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|ALL, BCR, breakpoint cluster region, CML, D22S11, D22S662, PHL|
|Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation|
|BCR Fusion Protein Ag18281|
|Antigen Affinity Chromatography|
|Human, Non-human primate|
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