BD Caspase-3, Active Form, mAb Apoptosis Kit
Specific recognision of active form of caspase-3 in human and mouse cells
Manufacturer: BD 550914
Cysteine proteases plays key role in apoptosis and inflammation. Caspase-3 being key protease is activated during early stages of apoptosis and, like other members of caspase family, is synthesized as inactive pro-enzyme that is processed in cells undergoing apoptosis by self-proteolysis and/or cleavage by another protease. The processed forms of caspases consist of large (17-22 kDa) and small (10-12 kDa) subunits which associate to form active enzyme. Active caspase-3, a marker for cells undergoing apoptosis, consists of heterodimer of 17 and 12 kDa subunits which is derived from the 32 kDa pro-enzyme. Active caspase-3 proteolytically cleaves and activates other caspases, as well as relevant targets in cytoplasm and nucleus. This antibody has been reported to specifically recognize the active form of caspase-3 in human and mouse cells.
- Clone: C92-605
- Format: PE
- Isotype: IgG
Intracellular staining (flow cytometry)
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Research use only