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Begacestat, Tocris Bioscience™

Catalog Number 428310
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
769169-27-9
C9H8ClF6NO3S2
391.727
PSXOKXJMVRSARX-SCSAIBSYSA-N
begacestat, unii-3666c56bbu, 5-chloro-n-1s-3,3,3-trifluoro-1-hydroxymethyl-2-trifluoromethyl propyl-2-thiophenesulfonamide, begacestat usan:inn, begacestat usan/inn, d09zvc, begacestat hplc, 2s-n-5-chlorothiophen-2-yl-4,4,4-trifluoro-1-hydroxy-3-trifluoromethyl butane-2-sulfonamido, 2-thiophenesulfonamide, 5-chloro-n-1s-3,3,3-trifluoro-1-hydroxymethyl-2-trifluoromethyl propyl, 5-chloro-n-1s-3,3,3-trifluoro-1-hydroxymethyl-2-trifluoromethyl propyl thiophene-2-sulfonamide
11269353
5-chloro-N-[(2S)-4,4,4-trifluoro-1-hydroxy-3-(trifluoromethyl)butan-2-yl]thiophene-2-sulfonamide
C1=C(SC(=C1)Cl)S(=O)(=O)NC(CO)C(C(F)(F)F)C(F)(F)F
This item is not returnable. View return policy
769169-27-9
C9H8ClF6NO3S2
391.727
PSXOKXJMVRSARX-SCSAIBSYSA-N
begacestat, unii-3666c56bbu, 5-chloro-n-1s-3,3,3-trifluoro-1-hydroxymethyl-2-trifluoromethyl propyl-2-thiophenesulfonamide, begacestat usan:inn, begacestat usan/inn, d09zvc, begacestat hplc, 2s-n-5-chlorothiophen-2-yl-4,4,4-trifluoro-1-hydroxy-3-trifluoromethyl butane-2-sulfonamido, 2-thiophenesulfonamide, 5-chloro-n-1s-3,3,3-trifluoro-1-hydroxymethyl-2-trifluoromethyl propyl, 5-chloro-n-1s-3,3,3-trifluoro-1-hydroxymethyl-2-trifluoromethyl propyl thiophene-2-sulfonamide
11269353
5-chloro-N-[(2S)-4,4,4-trifluoro-1-hydroxy-3-(trifluoromethyl)butan-2-yl]thiophene-2-sulfonamide
C1=C(SC(=C1)Cl)S(=O)(=O)NC(CO)C(C(F)(F)F)C(F)(F)F

Description

γ-secretase inhibitor; lowers Aβ40 and Aβ42 levels

γ-secretase inhibitor; selectively inhibits cleavage of amyloid precursor protein (APP) over Notch. Lowers levels of Aβ42 and Aβ40 (EC50 values are 12.4 and 14.8 nM respectively in cells expressing human recombinant APP). Orally active.
Quantity 10 mg
Formula Weight 391.74
Percent Purity >98%
Chemical Name or Material Begacestat

Safety and Handling

Recommended Storage Store at +4°C
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