Mouse anti-beta 2-Microglobulin, Clone: C21.48A1, Novus Biologicals
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP2444700.02MG
Ensure accurate, reproducible results in Flow Cytometry, Immunofluorescencebeta 2-Microglobulin Monoclonal antibody specifically detects beta 2-Microglobulin in Human, Primate samples. It is validated for Flow Cytometry, SDS-Page, Immunofluorescence.
|10mM PBS and 0.05% BSA with 0.05% Sodium Azide|
|beta chain of MHC class I molecules, beta-2-microglobin, beta-2-microglobulin|
|Protein A or G purified|
|Store at 4C.|
|The antibody recognizes the hidden determinant of beta-2 microglobulin (i.e. binding to its determinant is available only when the chain is separated from the HLA heavy chain. beta-2 microglobulin is a 12KDa protein with a pI of 5.6. Serum beta2 microglobulin levels are a reflection of cell turnover. Levels rise with fever, inflammation, and infection. Increased serum levels are also seen in B-cell malignancies and in renal failure and may indicate a worse prognosis for patients with early-stage Hodgkin's lymphoma. In urine, increased levels are seen in proximal renal tubular disease as well as renal transplant rejection. beta2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumours and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy).|
|Flow Cytometry, SDS-Page, Immunofluorescence|
|Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, SDS-Page, Immunofluorescence 0.5 - 1.0 ug/ml|
|Soluble beta 2 microglobulin|
|Adaptive Immunity, Cancer, Cell Biology, Diabetes Research, Immunology|
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