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beta Tubulin Mouse anti-Human, Clone: 2-28-33, Active Motif™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

$116.85 - $356.95

Specifications

Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Antigen beta Tubulin
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-199-3195 Non-distribution product as customer accommodation.
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Active MotifSupplier Diversity Partner
61158
10 μg
Each for $116.85
Add to cart
 
50-199-3194 Non-distribution product as customer accommodation.
View Documents
Active MotifSupplier Diversity Partner
61157
100 μg
Each for $356.95
Add to cart
 
Description

Description

Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Beta-III tubulin is primarily expressed in neurons and may be involved in neurogenesis, axon guidance and maintenance. Mutations in the beta tubulin gene are the cause of congenital fibrosis of the extraocular muscles type 3. Beta-III tubulin was also detected in Sertoli cells of the testis and transiently in non-neuronal embryonic tissues. Glutamate residues at the C-terminus of beta III tubulin can be glutamylated. The precise function of such modifications is unclear. Tubulin is phosphorylated on Ser-172 by CDK1 during cell cycle progression. Ser-172 phosphorylation inhibits tubulin incorporation into microtubules.Microtubules, the major cytoskeletal elements found in all eukaryotic cells, consist of Tubulin, which is a dimer of two 55 kDa subunits: alpha and Beta. Microtubules play key roles in chromosome segregation in mitosis, intracellular transport, ciliary and flagellar bending, and structural support of the cytoskeleton. Because beta-tubulin is ubiquitously expressed in all eukaryotic cells, it is frequently used as a loading control for assays involving protein detection, such as Western blotting.
Specifications

Specifications

Monoclonal
Primary
beta Tubulin
Unconjugated
SDS
Product Certifications
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