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BIBU 1361 dihydrochloride, Tocris Bioscience™

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Quantity:
1mg
10mg
This item is not returnable. View return policy
793726-84-8
C22H29Cl3FN7
516.871
ZNNWCQCQUKAMGL-UHFFFAOYSA-N
bibu 1361 dihydrochloride,n-3-chloro-4-fluorophenyl-6-4-diethylamino methyl piperidin-1-yl pyrimido 5,4-d pyrimidin-4-amine dihydrochloride,n-3-chloro-4-fluorophenyl-6-4-diethylamino methyl-1-piperidinyl-pyrimido 5,4-d pyrimidin-4-amine dihydrochloride,n-3-chloro-4-fluorophenyl-6-4-diethylamino methyl piperidin-1-yl pyrimido 5,4-d 1,3 diazin-4-amine dihydrochloride,n-3-chloro-4-fluorophenyl-6-4-diethylamino methyl piperidin-1-yl pyrimido 5,4-d pyrimidin-4-amine-hydrogen chloride 1/2,pyrimido 5,4-d pyrimidin-4-amine,n-3-chloro-4-fluorophenyl-6-4-diethylamino methyl-1-piperidinyl
46861539
N-(3-chloro-4-fluorophenyl)-6-[4-(diethylaminomethyl)piperidin-1-yl]pyrimido[5,4-d]pyrimidin-4-amine;dihydrochloride
CCN(CC)CC1CCN(CC1)C2=NC=C3C(=N2)C(=NC=N3)NC4=CC(=C(C=C4)F)Cl.Cl.Cl
This item is not returnable. View return policy
793726-84-8
C22H29Cl3FN7
516.871
ZNNWCQCQUKAMGL-UHFFFAOYSA-N
bibu 1361 dihydrochloride,n-3-chloro-4-fluorophenyl-6-4-diethylamino methyl piperidin-1-yl pyrimido 5,4-d pyrimidin-4-amine dihydrochloride,n-3-chloro-4-fluorophenyl-6-4-diethylamino methyl-1-piperidinyl-pyrimido 5,4-d pyrimidin-4-amine dihydrochloride,n-3-chloro-4-fluorophenyl-6-4-diethylamino methyl piperidin-1-yl pyrimido 5,4-d 1,3 diazin-4-amine dihydrochloride,n-3-chloro-4-fluorophenyl-6-4-diethylamino methyl piperidin-1-yl pyrimido 5,4-d pyrimidin-4-amine-hydrogen chloride 1/2,pyrimido 5,4-d pyrimidin-4-amine,n-3-chloro-4-fluorophenyl-6-4-diethylamino methyl-1-piperidinyl
46861539
N-(3-chloro-4-fluorophenyl)-6-[4-(diethylaminomethyl)piperidin-1-yl]pyrimido[5,4-d]pyrimidin-4-amine;dihydrochloride
CCN(CC)CC1CCN(CC1)C2=NC=C3C(=N2)C(=NC=N3)NC4=CC(=C(C=C4)F)Cl.Cl.Cl

Selective inhibitor of EGFR-kinase

Potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC 50 = 3 nM). Displays ∽ 100-fold lower potency against ErbB2 (IC 50 = 290 nM) and is selective over a range of other related tyrosine kinases (IC 50 > 10 μM). Blocks downstream EGFR signaling events such as MAPKK/MAPK activation. Oral administration inhibits growth of established human xenografts in athymic mice.
Quantity 1mg
Formula Weight 516.87
Percent Purity >97%
Chemical Name or Material BIBU 1361 dihydrochloride

Recommended Storage : Desiccate at +4°C