Invitrogen™ BICD1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA559508

Catalog No. PIPA559508

Description

Immunogen sequence: YRQSRVTRSG SLKGPDDPRG LLSPRLARRG VSSPVETRTS SEPVAKESTE ASKEPSPTKT PTISPVITAP PSSPVLDTSD IRKE Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.

BICD1 was initially identified as the human homolog to Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. BICD1 can bind to dynein-dynactin and co-localizes with Rab6A on the trans-Golgi network and cytoplasmic vesicles, suggesting BICD1 regulates COPI-independent Golgi-ER transport. BICD1 will also interact with Rab6B, a Rab6 isoform that is expressed primarily in brain. Live cell imaging showed bi-directional movement of Rab6B structures in SK-N-SH neurites, indicating that BICD1 is involved in the Rab6B regulation of retrograde cargo transport in neuronal cells.

Specifications

• Antigen: BICD1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BICD1
• Gene Alias: B830009D06Rik; bicaudal D homolog 1; bicaudal D homolog 1 (Drosophila); BICD; bic-D 1; BICD cargo adaptor 1; BICD1; cytoskeleton-like bicaudal D protein homolog 1; protein bicaudal D homolog 1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 636
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96G01
• Gene Symbols: BICD1
• Immunogen: Recombinant protein corresponding to Human BICD1. Recombinant protein control fragment (Product #RP-97780).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG