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BIN1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA551104

Catalog No. PA551104


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Description

Description

BIN1 Polyclonal Antibody detects endogenous levels of BIN1 protein.

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dyim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
Specifications

Specifications

BIN1
Polyclonal
Unconjugated
BIN1
Liquid
BIN1
Synthesized peptide derived from the C-terminal region of human Amphiphysin II.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
ELISA, Western Blot
1 mg/mL
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
O00499, O08539, O08839
AMPHL
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
117028, 274, 30948
Documents
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