Tocris™ BIRT 377

Potent negative allosteric modulator of LFA-1

Manufacturer: Tocris™ 4776/10

 View all options for this product

Catalog No. 47-761-0

  Check Availability
Add to Cart


For Research Use Only


    Product Type BIRT 377
    Inhibitors BIRT 377
    Purity >98
    Molecular Weight 442.13
    Quantity 10mg

    Potent negative allosteric modulator of LFA-1 (lymphocyte function-associated antigen-1) (Kd = 26nM). Binds to the I-domain of LFA-1. Reversibly inhibits LFA-1 mediated binding of SKW3 leukemia cells to ICAM-1. Inhibits superantigen (SEB)-induced IL-2 production from lymphocytes in vitro and attenuates the SEB-induced increase in IL-2 plasma levels in a mouse model in vivo. Orally available.

    • Chemical Name: (5R)-5-[(4-Bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethyl-2,4-imidazolidinedione
    • Formula: C18H15BrCl2N2O2
    • CAS Number: 213211-10-0
    • Solubility: Soluble to 100mM in DMSO and to 50mM in ethanol
    • Purity: >98

  • Description & Specifications

Related Products

Product Content Feedback

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit