Tocris BIRT 377
Potent negative allosteric modulator of LFA-1
Manufacturer: Tocris 4776/10
DescriptionPotent negative allosteric modulator of LFA-1 (lymphocyte function-associated antigen-1) (Kd = 26nM). Binds to the I-domain of LFA-1. Reversibly inhibits LFA-1 mediated binding of SKW3 leukemia cells to ICAM-1. Inhibits superantigen (SEB)-induced IL-2 production from lymphocytes in vitro and attenuates the SEB-induced increase in IL-2 plasma levels in a mouse model in vivo. Orally available.
- Chemical Name: (5R)-5-[(4-Bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethyl-2,4-imidazolidinedione
- Formula: C18H15BrCl2N2O2
- CAS Number: 213211-10-0
- Solubility: Soluble to 100mM in DMSO and to 50mM in ethanol
- Purity: >98
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