Tocris BIX 02189
Selective MEK5 and ERK5 inhibitor
Manufacturer: Tocris 4842/10
DescriptionSelective MEK5 and ERK5 inhibitor (IC50 values are 1.5 and 59nM respectively). Inhibits sorbitol-induced ERK5 phosphorylation in HeLa cells. Selective for MEK5 and ERK5 over MEK1/2, ERK1/2 and a panel of 87 kinases. Induces apoptosis in acute myeloid leukemia tumor cells.
- Chemical Name: (3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide
- Formula: C27H28N4O2
- CAS Number: 1265916-41-3
- Solubility: Soluble to 100mM in DMSO and to 100mM in 1eq. HCl
- Purity: >98
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