Tocris™ BIX 02189

Selective MEK5 and ERK5 inhibitor

Manufacturer: Tocris™ 4842/10

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Catalog No. 48-421-0

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Disclaimers:

For Research Use Only


    Specifications

    Product Type BIX 02189
    Inhibitors BIX 02189
    Purity >98
    Molecular Weight 440.54
    Quantity 10mg

    Selective MEK5 and ERK5 inhibitor (IC50 values are 1.5 and 59nM respectively). Inhibits sorbitol-induced ERK5 phosphorylation in HeLa cells. Selective for MEK5 and ERK5 over MEK1/2, ERK1/2 and a panel of 87 kinases. Induces apoptosis in acute myeloid leukemia tumor cells.

    • Chemical Name: (3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide
    • Formula: C27H28N4O2
    • CAS Number: 1265916-41-3
    • Solubility: Soluble to 100mM in DMSO and to 100mM in 1eq. HCl
    • Purity: >98

  • Description & Specifications

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