Thermo Scientific Chemicals Blasticidin S hydrochloride, 10 mg/ml in HEPES buffer, sterile-filtered

Description

Blasticidin S hydrochloride, CAS # 3513-03-9, is an antibiotic isolated from Streptomyces griseochromogenes that inhibits peptide bond formation by ribosome.

Blasticidin S hydrochloride, acts quickly by inhibiting peptide bond formation by the ribosome. The blasticidin S resistance gene (BSR), found in Bacillus cereus K55-S1, has been used in multiple studies for its use as a selective compound. Resistance is conferred by expression of one of two Blasticidin S deaminase genes: BSD from Aspergillus terreus or bsr from Bacillus cereus. These deaminases convert Blasticidin S to a nontoxic deaminohydroxy derivative. Blasticidin S is used for the prevention of contamination of cell cultures.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Blasticidin S hydrochloride is an antibiotic that works by inhibiting peptide bond formation by the ribosome

Application

• Blasticidin S hydrochloride is a nucleoside antibiotic that inhibits protein synthesis in prokaryotic and eukaryotic cells
• It inhibits peptide bond formation by the ribosome

Specifications

• Type: Blasticidin S Hydrochloride
• Physical Form: Liquid
• Solubility Information: Soluble in water. Insoluble in organic solvents.
• SMILES: CN(CCC(CC(=O)NC1C=CC(OC1C(=O)O)N2C=CC(=NC2=O)N)N)C(=N)N.Cl
• IUPAC Name: (2R,3S,6S)-3-[[(3R)-3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxopyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylic acid;hydrochloride
• PubChem CID: 124080960
• Concentration: 10mg/mL in HEPES buffer
• Quantity: 5 x 1 mL
• Chemical Name or Material: Blasticidin S hydrochloride, sterile-filtered

Safety and Handling

Hazard Category	Warning
Hazard Statement	GHS H Statement H302 Harmful if swallowed.
Precautionary Statement	GHS P Statement P264-P270-P301+P312-P330-P501a Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. Dispose of contents/container in accordance with local/regional/national/international regulations.
TSCA	No
storageNote1	−30° to −10°C
Recommended Storage	Store at -20°C

SDS

RUO – Research Use Only