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BLNK Mouse anti-Human, Clone: OTI4C9, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527007

Catalog No. PIMA527007


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Description

Description

This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Specifications

Specifications

BLNK
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q8WV28
AGM4, BASH, BLNK-S, LY57, SLP-65, SLP65, bca, B cell adaptor containing SH2 domain; B cell linker protein; B-cell activation; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; B-cell linker protein; Src homology 2 domain-containing leukocyte protein of 65 kDa; Src homology [SH2] domain-containing leukocyte protein of 65 kD; cytoplasmic adapter protein
Mouse
IgG2b
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
29760
Immunohistochemistry (Paraffin), Western Blot
OTI4C9
Unconjugated
BLNK
Liquid
BLNK
Human recombit protein fragment corresponding to amino acids 1-292 of BLNK produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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