BLNK Mouse anti-Human, Clone: OTI4C9, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527007
DescriptionThis gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|AGM4, BASH, BLNK-S, LY57, SLP-65, SLP65, bca, B cell adaptor containing SH2 domain; B cell linker protein; B-cell activation; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; B-cell linker protein; Src homology 2 domain-containing leukocyte protein of 65 kDa; Src homology [SH2] domain-containing leukocyte protein of 65 kD; cytoplasmic adapter protein|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Human recombit protein fragment corresponding to amino acids 1-292 of BLNK produced in E.coli|
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