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BMAL1 Mouse anti-Canine, Human, Rat, Clone: OTI3G9, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525133

Catalog No. PIMA525133


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Description

Description

Circadian rhythmicity is a basic property of phylogenetically diverse organisms which range from animals and plants, to fungi. Regulation of endogenous biological clocks is regulated at the genetic level by a protein-mediated, autoregulatory feed-back loop. In mammals, several genes that encode members of the basic helix-loop helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Transactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-ARNT3 heterodimers bind to E box regulatory elements and stimulate gene transcription. CLOCK has been shown to transactivate the mammalian homolog of Drosophila per. PER, in concert with the product of the mammalian timeless gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL1 transactivation complex.
Specifications

Specifications

BMAL1
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
O00327, Q9EPW1
ARNTL; BMAL1; aryl hydrocarbon receptor nuclear translocator-like; BMAL1c; JAP3; MGC47515; MOP3; PASD3; TIC; ARNT-like protein 1, brain and muscle; bHLH-PAS protein JAP3; basic-helix-loop-helix-PAS orphan MOP3; member of PAS superfamily 3
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
29657, 406, 476860
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot
OTI3G9
Unconjugated
ARNTL
Liquid
ARNTL
Full length human recombit protein of ARNTL produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Canine, Human, Rat
Documents
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