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Bmf Mouse anti-Human, Clone: OTI9B7, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526878

Catalog No. PIMA526878



Description

Description

Apoptosis is related to many diseases and development. Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3-only proteins, including Bad, Bid, Bik, Hrk, Bim, Noxa, and PUMA, form a growing subclass of the Bcl-2 family. A novel BH3-only protein was recently identified in human and mouse and designated Bmf (for Bcl-2-modifing factor). The BH3 domain in Bmf is required both for binding to Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf associates with the dynein light chain 2 (DLC2) component of the myosin V motors and is sequestered by the cell ft.s actin cytoskeleton. Disruption of the actin cytoskeleton, either by depolymerization of actin filaments or by detachment of cells from the extracellular matrix, triggers release and activation of Bmf, initiating the downstream apoptotic program. Bmf is constitutively expressed in many tissues.
Specifications

Specifications

Bmf
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q96LC9
bcl-2-modifying factor
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
90427
Immunohistochemistry (Paraffin), Western Blot
OTI9B7
Unconjugated
BMF
Liquid
BMF
Full length human recombit protein of BMF produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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