BMI-1 Monoclonal Antibody (AF27), Active Motif™

Mouse Monoclonal Antibody

Supplier:  Active Motif 39994

Catalog No. 50-199-3024

Description

Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

Specifications

• Antigen: BMI-1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: 70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
• Gene Accession No.: P25916, P35226
• Gene Symbols: BMI1
• Immunogen: This BMI-1 antibody was raised against a recombinant protein corresponding to full-length mouse BMI-1.
• Quantity: 10 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG2a

• Applications: ChIP sequencing (ChIP-seq), Western Blot
• Clone: AF27
• Conjugate: Unconjugated
• Gene: BMI1
• Gene Alias: AW546694; B lymphoma Mo-MLV insertion region 1; B lymphoma Mo-MLV insertion region 1 homolog; Bmi1; Bmi-1; BMI1 polycomb ring finger oncogene; BMI1 polycomb ring finger proto-oncogene; BMI1 proto-oncogene, polycomb ring finger; FLVI2/BMI1; flvi-2/bmi-1; murine leukemia viral (bmi-1) oncogene homolog; PCGF4; Pcgf4 antibody; Polycomb complex protein BMI-1; polycomb group protein Bmi1; polycomb group ring finger 4; Polycomb group RING finger protein 4; RING finger protein 51; RNF51; RP11-573G6.1
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 12151, 648
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid