Tocris BMS 195614
Selective RARalpha antagonist
Manufacturer: Tocris 3660/10
DescriptionNeutral retinoic acid receptor (RAR) α-selective antagonist (Ki = 2.5nM). Displays no significant effect on nuclear receptor corepressor (NCoR) binding; moderately decreases SMRT binding to RAR. Antagonizes agonist-induced coactivator (CoA) recruitment.
- Chemical Name: 4-[[[5,6-Dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]benzoic acid
- Formula: C29H24N2O3
- CAS Number: 253310-42-8
- Solubility: Soluble to 25mM in DMSO
- Purity: >98
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