Tocris BMS 309403
Potent and selective FABP4 inhibitor
Manufacturer: Tocris 5258/10
DescriptionPotent and selective fatty acid binding protein 4, adipocyte (FABP4) inhibitor (Ki values are <2, 250 and 350nM for FABP4, FABP3 and FABP5 respectively). Decreases fatty acid uptake in adipocytes in vitro and reduces atherosclerotic lesion area in a mouse model of atherosclerosis. Reduces blood glucose levels and increases insulin sensitivity in a mouse model of obesity. Orally active.
- Chemical Name: 2-[[2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]-acetic acid
- Formula: C31H26N2O3
- CAS Number: 300657-03-8
- Solubility: Soluble to 100mM in DMSO
- Purity: >98
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