Tocris Bioscience™ BMS 509744

Potent and selective ITK inhibitor

Supplier:  Tocris Bioscience™ 5009/10

Catalog No. 50-091-0R

Description

BMS 509744 is a potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitor (IC50 = 19 nM). Displays 200-fold selectivity over Tec family kinases and 55-fold selectivity over other kinases tested. Reduces HIV infection of primary CD4+ T cells and attenuates the establishment of HIV infection in vitro. Reduces T cell proliferation and IL-2 production in vitro. Reduces lung inflammation in a mouse model of ovalbumin-induced allergy/asthma.

Specifications

• Purity: 97%
• CAS: 439575-02-7
• Quantity: 10 mg
• Molecular Weight (g/mol): M.W. (Observed): 623.83

• Molecular Formula: N-[5-[[5-[(4-Acetyl-1-piperazinyl)carbonyl]-4-methoxy-2-methylphenyl]thio]-2-thiazolyl]-4-[[(1,2,2-trimethylpropyl)amino]methyl]benzamide
• Content And Storage: -20°C
• Product Type: BMS 509744
• Inhibitors: BMS 509744

For Research Use Only