Tocris Bioscience™ BMS 509744
Potent and selective ITK inhibitor
Supplier: Tocris Bioscience™ 5009/10
DescriptionBMS 509744 is a potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitor (IC50 = 19 nM). Displays 200-fold selectivity over Tec family kinases and 55-fold selectivity over other kinases tested. Reduces HIV infection of primary CD4+ T cells and attenuates the establishment of HIV infection in vitro. Reduces T cell proliferation and IL-2 production in vitro. Reduces lung inflammation in a mouse model of ovalbumin-induced allergy/asthma.
|M.W. (Observed): 623.83|
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For Research Use Only