Non-competitive GC inhibitor. Also AC inhibitor
Manufacturer: Tocris 3635/50
DescriptionNon-competitive guanylyl cyclase (GC) and adenylyl cyclase (AC) inhibitor. Downregulates cAMP and cGMP synthesis, and suppresses cGMP accumulation in a variety of cell lines (IC50 = 3.4 - 11.2µM). Inhibits GC-stimulated Cl- transport in vitro and suppresses toxin-induced intestinal fluid accumulation in vivo.
- Chemical Name: 5-(3-Bromophenyl)-5,11-dihydro-1,3-dimethyl-1H-indeno[2',1':5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione
- Formula: C22H16BrN3O3
- CAS Number: 325746-94-9
- Solubility: Soluble to 2mM in DMSO
- Purity: >99
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