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BTK Mouse anti-Human, Clone: OTI10E10, liquid, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner TA501118S

Catalog No. 50-167-2262


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Description

Description

BTK (Bruton ft.s tyrosine kinase or tyrosine-protein kinase BTK) was initially identified as a member of the src family for protein-tyrosine kinases that was involved in X-linked a-gamma-globulinaemia, and has since been shown to be involved in a number of signaling pathways in hemapoietic lineage. It has recently been shown to interact with members of the toll-like receptor (TLR) family such as TLR4, 6, 8, and 9. The TLRs are critical molecules in both the innate and adaptive immunity and can recognize diverse microbial pathogens. BTK has also been shown to interact with key proteins involved in TLR4 signal transduction such as MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting that BTK is involved in lipopolysaccharide signal transduction. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement.
Specifications

Specifications

BTK
Monoclonal
0.87 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Q06187
AGMX1, AT, ATK, BPK, IMD1, PSCTK1, XLA
Mouse
IgG2a
30 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
695
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI10E10
Unconjugated
BTK
Liquid
BTK
Full length human recombit protein of human BTK produced in HEK293T cell.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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