BTK Monoclonal Antibody (OTI13E5), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA501102

Catalog No. 50-167-2246

Description

BTK (Bruton′s tyrosine kinase or tyrosine-protein kinase BTK) was initially identified as a member of the src family for protein-tyrosine kinases that was involved in X-linked a-gamma-globulinaemia, and has since been shown to be involved in a number of signaling pathways in hemapoietic lineage. It has recently been shown to interact with members of the toll-like receptor (TLR) family such as TLR4, 6, 8, and 9. The TLRs are critical molecules in both the innate and adaptive immunity and can recognize diverse microbial pathogens. BTK has also been shown to interact with key proteins involved in TLR4 signal transduction such as MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting that BTK is involved in lipopolysaccharide signal transduction. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement.

Specifications

• Antigen: BTK
• Classification: Monoclonal
• Concentration: 0.95 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q06187
• Gene Symbols: BTK
• Immunogen: Full length human recombit protein of human BTK produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot
• Clone: OTI13E5
• Conjugate: Unconjugated
• Gene: BTK
• Gene Alias: AGMX1, AT, ATK, BPK, IMD1, PSCTK1, XLA
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 695
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid