Tocris BTT 3033
Selective inhibitor of integrin alpha2beta1
Manufacturer: Tocris 4724/10
DescriptionSelective inhibitor of integrin α2β1 (EC50 = 130nM for α2β1 binding to collagen I). Binds to the α2I domain. Exhibits selectivity for α2β1 over integrins α3β1, α4β1, α5β1 and αv. Inhibits platelet aggregation to collagen I coated capillaries under flow. Also inhibits binding of α2-expressing CHO cells to collagen I under shear stress conditions.
- Chemical Name: 1-(4-Fluorophenyl)-N-methyl-N-[4[[(phenylamino)carbonyl]amino]phenyl]-1H-pyrazole-4-sulfonamide
- Formula: C23H20FN5O3S
- CAS Number: 1259028-99-3
- Solubility: Soluble to 100mM in DMSO
- Purity: >98
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