Tocris BVT 948
Non-competitive protein tyrosine phosphatase inhibitor; enhances insulin signaling
Manufacturer: Tocris 2176/50
DescriptionNon-competitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC50 = 0.09 - 1.7µM); displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. Enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo. Also inhibits several cytochrome P450 isoforms (IC50 < 10µM).
- Chemical Name: 4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione
- Formula: C14H11NO3
- CAS Number: 39674-97-0
- Solubility: Soluble to 50mM in ethanol and to 50mM in DMSO
- Purity: >98
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