Tocris™ BVT 948

Non-competitive protein tyrosine phosphatase inhibitor; enhances insulin signaling

Manufacturer: Tocris™ 2176/10

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Catalog No. 21-761-0

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For Research Use Only


    Product Type BVT 948
    Inhibitors BVT 948
    Purity >98
    Molecular Weight 241.25
    Quantity 10mg

    Non-competitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC50 = 0.09 - 1.7µM); displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. Enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo. Also inhibits several cytochrome P450 isoforms (IC50 < 10µM).

    • Chemical Name: 4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione
    • Formula: C14H11NO3
    • CAS Number: 39674-97-0
    • Solubility: Soluble to 50mM in ethanol and to 50mM in DMSO
    • Purity: >98

  • Description & Specifications

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