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Epredia™ Lab Vision™ c-Abl Ab-1 Mouse Monoclonal Antibody, biotin labeled with BSA and azide
Obtain accurate, reproducible results in immunohistochemistry, western blotting, immunofluorescence, and immunoprecipitation procedures.
Supplier: Epredia™ MS938R1
Description
The c-Abl proto-oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome). As the result of the fusion of c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase.
Host Species: Mouse
Clone: 8E9
Isotype: IgG1/γ
Species Reactivity: Human and Mouse. Others not tested.
Epitope: SH2 domain
Immunogen: Recombinant Abl protein
Molecular Weight: 120kDa
Positive Control: HeLa cells or placenta
Cellular Localization: Cytoplasmic and nuclear
Ab-1 reacts with c-Abl p120 and chimeric Bcr/Abl proteins.
Recommended for:
- Immunohistochemistry (Formalin/paraffin)
- Western Blotting
- Immunofluorescence
- Immunoprecipitation
Note:
USA: RUO; Int'l: RUO
Specifications
c-Abl Ab-1 | |
Monoclonal | |
Unconjugated | |
Mouse | |
1 mL | |
Signal Transduction | |
Human, Mouse | |
IgG1 |
Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
8E9 | |
Ready-to-use for IHC (UVLP) | |
Recombinant Abl protein | |
RUO | |
Primary | |
Prediluted |
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