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c-MAF Mouse anti-Human, Mouse, eFluor™ 450, Clone: sym0F1, eBioscience™

Mouse Monoclonal Antibody

Manufacturer:  eBioscience 48985542

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Catalog No. 48-985-542


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Description

Description

The sym0F1 monoclonal antibody reacts with human and mouse c-Maf, a 42 kDa basic leucine zipper transcription factor shown to be involved in the neural, ocular and hematopoietic systems. In hematopoietic cells, it was first shown to be crucial for IL-4 ex

eFluor 450 is a alternative to Pacific Blue. eFluor 450 emits at 445 nm and is excited with the violet laser line (405 nm). Please make sure that your instrument is capable of detecting this fluorochrome. Excitation: 405 nm; Emission: 445 nm; Laser: Violet Laser c-maf is the cellular counterpart of oncogenic v-maf that belongs to the family of basic region leucine zipper domain transcription factors. The leucine-zipper domain is involved in the interaction with LRPICD. There are two forms of human c-maf mRNA, c-maf-long and c-maf-short. It is identified in the genome of the acute transforming avian retrovirus AS42. c-maf targets are IL-4 in Th2 cells, the crystalline genes in lens fiber cells, insulin gene in islet , p53 and L7 where it exerts its transcriptional role through binding to a Maf recognition element (MARE). It regulates Th2 differentiation and lineage-specific hematopoiesis. c-maf is a transcription factor for IL-10 gene expression in LPS-activated macrophages. Chromosomal aberration involving maf is found in some forms of multiple myeloma. It is expressed in myeloma cell lines and resting monocytes/macrophages.
Specifications

Specifications

c-MAF
Monoclonal
5 μL/Test
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
O75444, P54843
2810401A20Rik; A230108G15Rik; AW047063; AYGRP; c-MAF; CCA4; CTRCT21; MAF; Maf2
Mouse
Affinity Chromatography
RUO
Antibody
Monoclonal
Human, Mouse
Flow Cytometry
sym0F1
eFluor™ 450
MAF
Liquid
MAF
IgG2b, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
17132, 4094
Documents
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