C14orf129 Mouse anti-Human, Clone: 2F2, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA524550
Peptide Sequence: METDCNPMEL SSMSGFEEGS ELNGFEGTDM KDMRLEAEAV VNDVLFAVNN MFVSKSLRCA DDVAYINVET KERNRYCLEL TEAGLKVVGY AFDQVDDHLQ TPYHETVYSL LDTLSPAYRE AFGNALLQRL EALKRDGQSThis gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene.
|C14orf129 (NP_057556.2, 1 a.a. ∽ 139 a.a) full-length recombit protein with GST tag. MW of the GST tag alone is 26 KDa.|
|ELISA, Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with no preservative; pH 7.4|
|GSKIP, HSPC210, MGC4945|
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