Invitrogen™ C16orf62 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA528553

Catalog No. PIPA528553

Description

Recommended positive controls: 293T, A431, H1299, HeLaS3, Molt-4, Raji. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) (PubMed:28892079). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes (PubMed:28892079). In the endosomes, drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (PubMed:28892079). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association with the CCC complex and cooperation with the WASH complex on early endosomes. Seems not to be required for CCC complex stability (PubMed:25355947). [UniProt].

Specifications

• Antigen: C16orf62
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: C16orf62
• Gene Alias: 101F10.2; C16orf62; chromosome 16 open reading frame 62; esophageal cancer associated protein; esophageal cancer-associated protein; UPF0505 protein C16orf62; VPS35 endosomal protein sorting factor-like; VPS35L
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57020
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q7Z3J2
• Gene Symbols: C16orf62
• Immunogen: Recombinant protein fragment corresponding to a region within amino acids 1 and 228 of Human C16orf62.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov