C17orf96 Rabbit anti-Mouse, Unconjugated, Polyclonal, Active Motif™
Rabbit Polyclonal Antibody
Manufacturer: Active Motif 61754
DescriptionElongin BC and Polycomb repressive complex 2-associated protein (EPOP) also know as C17ORF96 is a scaffold protein that serves as a bridging partner between the PRC2/EED-EZH2 complex and the elongin BC complex. It is required to fine tune the transcriptional status of polycomb group (PcG) target genes in embryonic stem cells (ESCs). C17ORF96 also plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression of PcG target genes. It acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EED-EZH2 complex. C17ORF96 also has interacts with USP7 and promotes deubiquitination of H2B at promoter sites.
|-20°C, Avoid Freeze/Thaw Cycles|
|70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8|
|AA409164; AI413509; AW539173; C17orf96; C9H17orf96; chromosome 17 open reading frame 96; chromosome 9 open reading frame, human C17orf96; E13; E130012A19Rik; Elongin BC and Polycomb repressive complex 2-associated protein; Embryonic stem cell-specific PRC2 subunit p48; EPOP; ES cell-specific PRC2 subunit p48; esPRC2p48; hypothetical protein LOC691153; LOC691153; proline rich 28; Proline-rich protein 28; PRR28; RIKEN cDNA E130012A19 gene; uncharacterized protein C17orf96; uncharacterized protein C17orf96 homolog; Uncharacterized protein ENSP00000317905|
|This antibody was raised against a recombinant protein corresponding to amino acids 59-229 of mouse C17orf96.|
|Antigen affinity chromatography|
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