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C6orf173 Rabbit anti-Human, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 245091AP

Catalog No. 50-173-4396


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Description

Description

CENPW was initially identified as a gene that was upregulated in multiple cancers, and whose overexpression in mouse fibroblast cells gave rise to distinct cancer-specific phenotypes. It was later found to be a nuclear protein that associated with CENPT, a component of CENPA nucleosome complex in the centromere, and is required for proper kinetochore function. CENPW also specifically interacts with the nucleolar phosphoprotein nucleophosmin, also known as B23 It has been suggested that nucleophosmin functions in the assembly of the kinetochore by interacting with CENPW during interphase. Overexpression of CENPW in the SKOV-3 human ovarian cancer cell line as well as in the zebrafish embryo led to apoptosis, suggesting that high levels of CENPW induces apoptotic cell death.
Specifications

Specifications

C6orf173
0.34 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q5EE01
C6orf173, CENP W, CENPW, Centromere protein W, CUG2
Rabbit
IgG
150 μL
-20°C
Primary
387103
Western Blot
Unconjugated
CENPW
Liquid
CENPW
C6orf173 Fusion Protein Ag21580
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Documents
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