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CAB39 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550709

Catalog No. PA550709


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Description

Description

The antibody detects endogenous levels of total CAB39 protein.

Peutz-Jeghers Syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules of the lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. The serine/threonine kinase LKB1 (also designated STK11) has been identified as the gene mutated in PJS. LKB1 activity increases upon the binding of a regulatory complex consisting of the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase and the calcium binding protein 39 (MO25 alpha). STRAD and MO25 determine the subcellular localization of LKB1 by initiating its translocation from the nucleus to the cytoplasm, thus regulating the tumor suppressor activity of LKB1. The LKB1/STRAD/MO25 complex acts as an AMP-activated protein kinase kinase (AMPKK).
Specifications

Specifications

CAB39
Polyclonal
Unconjugated
CAB39
Liquid
CAB39
Synthetic peptide corresponding to a region derived from internal residues of human calcium binding protein 39
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
2.9 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q9Y376
MO25
Rabbit
IgG
100 μL
-20°C
Primary
51719
Documents
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