Invitrogen™ CABP7 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA589372

Catalog No. PIPA589372

Description

Immunogen sequence: PKLSTSGIPE KFHGTDFDTV FWKCDMQKLT VDELKRLLYD TFCEHLSMKD IENIIMTEEE SHLGTAEECP VDVETCSNQQ I; Positive Samples: Mouse brain, Mouse lung, Mouse kidney, Rat lung, Rat kidney; Cellular Location: Cell membrane, Cytoplasm, Golgi apparatus, Single-pass type IV membrane protein, perinuclear region, trans-Golgi network membrane.

Calcium binding proteins (CaBP) play a crucial role in the calcium-mediated cellular signal transduction pathway in the central nervous system. The CaBP family shares much similarity with CaM I (calmodulin), and it has been shown that CaBP proteins can substitute functionally for, and possibly augment the function of, CaM I. CaBP7 (Calcium-binding protein 7), contains two EF-hand domains for calcium binding and shares 70% homology with CaBP8 and 50% homology with CaM I. It negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. CaBP7 and 8 possess a targeting mechanism that is unique amongst the CaBPs that may contribute to differential functional Ca2+-sensing by these family members.

Specifications

• Antigen: CABP7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CABP7
• Gene Alias: CABP7; calcium binding protein 7; calcium-binding protein 7; calcium-binding protein CaBP7; CALN2; calneuron 2; calneuron II; Calneuron-2; calneuron-II; rCaBP7
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 164633, 192650, 360970
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.21 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q66H96, Q86V35, Q91ZM8
• Gene Symbols: CABP7
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 100-180 of human CABP7 (NP_8723331).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG