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CaV2.1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550634

Catalog No. PA550634


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Description

Description

The antibody detects endogenous levels of total CACNA1A protein.

Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predomitly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the n-repeats occur in the 3 ft. UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the n-repeats which encode a polyglutamine tract. Expansion of the n-repeats from the normal 4-16 to 21-28 in the coding region is associated with spinocerebellar ataxia 6.
Specifications

Specifications

CaV2.1
Polyclonal
Unconjugated
CACNA1A
Liquid
CACNA1A
Synthetic peptide corresponding to a region derived from internal residues of human calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin)
1.5 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
O00555
BI, EA2, FHM, MHP, APCA, HPCA, MHP1, SCA6, CAV2.1, CACNL1A4
Rabbit
IgG
100 μL
-20°C
Primary
773
Documents
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