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CACTIN Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA560003

Catalog No. PIPA560003


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Description

Description

Immunogen sequence: TGFEWNKYNQ THYDFDNPPP KIVQGYKFNI FYPDLIDKRS TPEYFLEACA DNKDFAILRF HAGPPYEDIA FKIVNREWEY SHRHGFRCQF ANGIFQLWFH Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.

Cactin is a novel negative regulator of TLR signaling and reveals its capacity to target MHC Class III genes at the molecular and functional level. It is localized to the nucleus, which is critical for manifesting its inhibitory effects on TLR signaling. Experimental evidences show overexpression of Cactin suppresses TLR-induced activation of NF-kB and interferon-regulatory factor transcription factors and induction of TLR-responsive genes. It is also reported Cactin interacts with IkB-like protein and targets other proteins that are encoded by genes in the MHC Class III region of chromosome 6.
Specifications

Specifications

CACTIN
Polyclonal
Unconjugated
CACTIN
Liquid
CACTIN
Recombit protein corresponding to Human CACTIN
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry
0.05 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Q8WUQ7
NY-REN-24, cactin, fSAPc, NY REN 24 antigen, NY-REN-24 antigen, cactin homolog, functional spliceosome-associated protein c, renal carcinoma antigen NY-REN-24, uncharacterized protein C19orf29
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
58509
Documents
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