CACTIN Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA560003
Immunogen sequence: TGFEWNKYNQ THYDFDNPPP KIVQGYKFNI FYPDLIDKRS TPEYFLEACA DNKDFAILRF HAGPPYEDIA FKIVNREWEY SHRHGFRCQF ANGIFQLWFH Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.Cactin is a novel negative regulator of TLR signaling and reveals its capacity to target MHC Class III genes at the molecular and functional level. It is localized to the nucleus, which is critical for manifesting its inhibitory effects on TLR signaling. Experimental evidences show overexpression of Cactin suppresses TLR-induced activation of NF-kB and interferon-regulatory factor transcription factors and induction of TLR-responsive genes. It is also reported Cactin interacts with IkB-like protein and targets other proteins that are encoded by genes in the MHC Class III region of chromosome 6.
|Recombit protein corresponding to Human CACTIN|
|Antigen affinity chromatography|
|PBS with 40% glycerol and 0.02% sodium azide; pH 7.2|
|NY-REN-24, cactin, fSAPc, NY REN 24 antigen, NY-REN-24 antigen, cactin homolog, functional spliceosome-associated protein c, renal carcinoma antigen NY-REN-24, uncharacterized protein C19orf29|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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