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MilliporeSigma™ Calbiochem™ A77 1726

Blocks TNF-dependent NF-κB activation gene expression, inhibits activity of dihydroorotate dehydrogenase.

Manufacturer:  MilliporeSigma™ 1001285MG

Catalog No. 10-012-85MG

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  • Cell-permeable, reversible, substrate competitive inhibitor that inhibits IL-2-induced tyrosine phosphorylation of JAK1 JAK3
  • Reported to reduce IFN-γ-induced expression of iNOS in L929 fibroblasts
  • Inhibits IL-1β-induced activation of COX-2 PGE2 synthesis (IC50 = 130nM) in A549 cells
  • Assay: ≥97% by HPLC
  • CAS: 108605-62-5
  • Molecular Formula: C12H9F3N2O2
  • Color: White


2°C to 8°C
5 mg


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