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MilliporeSigma™ Calbiochem™ Calphostin C, Cladosporium cladosporioides
A cell permeable, highly specific inhibitor of protein kinase C (IC50 = 50nM) that interacts with the protein's regulatory domain by competing at the binding site of diacylglycerol and phorbol esters.
Supplier: MilliporeSigma™ 208725100UG
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DescriptionA cell permeable, highly specific inhibitor of protein kinase C (IC50 = 50nM) that interacts with the protein’s regulatory domain by competing at the binding site of diacylglycerol and phorbol esters. Does not compete with Ca2+ or phospholipids. At higher concentrations inhibits myosin light chain kinase (IC50 > 5μM), protein kinase A (IC50 > 50μM), protein kinase G (IC50 > 25μM), and p60v- src (IC50 > 50μM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Requires brief exposure to light for activation.
|95% by HPLC|
|Protect from light|
|DMSO or EtOH|
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