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MilliporeSigma™ Calbiochem™ Calphostin C, Cladosporium cladosporioides
A cell permeable, highly specific inhibitor of protein kinase C (IC50 = 50nM) that interacts with the protein's regulatory domain by competing at the binding site of diacylglycerol and phorbol esters.
Supplier: MilliporeSigma™ 208725100UG
Description
A cell permeable, highly specific inhibitor of protein kinase C (IC50 = 50nM) that interacts with the protein’s regulatory domain by competing at the binding site of diacylglycerol and phorbol esters. Does not compete with Ca2+ or phospholipids. At higher concentrations inhibits myosin light chain kinase (IC50 > 5μM), protein kinase A (IC50 > 50μM), protein kinase G (IC50 > 25μM), and p60v- src (IC50 > 50μM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Requires brief exposure to light for activation.Specifications
| Lyophilized Solid | |
| 100 μg | |
| 95% by HPLC | |
| 121263-19-2 | |
| 790.8g/mol |
| Protect from light | |
| Light Brown | |
| PKC | |
| C44H38O14 | |
| DMSO or EtOH |
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