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MilliporeSigma™ Calbiochem™ Adenosine A3 Receptor Antagonist, MRS 1523

A pyridine derivative that acts as a highly selective antagonist of A3 receptor with excellent potency in both humans and rodents (Ki

Manufacturer:  MilliporeSigma™ 1191525MG

Catalog No. 11-915-25MG


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Description

Description

A pyridine derivative that acts as a highly selective antagonist of A3 receptor with excellent potency in both humans and rodents (Ki = 18.9nM for human A3R, and 113nM for rat A3R). Exhibits only a trivial antagonistic activity towards A1 and A2A receptors (Ki = 15.6µM and 2.05µM for rat A1R and A2AR, respectively). Abolishes the agonistic effects of Cl-IB-MECA (Cat. No. 119139) on A3R-mediated proliferation of primary human coronary smooth muscle cells. Also, reported to block NECA (Cat. No. 119140)-induced bronchoconstriction in an allergic murine model.
Specifications

Specifications

95% by HPLC
Protect from Light
A3 Receptor
C23H29NO3S
DMSO
Clear, colorelss oil
5mg
212329-37-8
399.55g/mol
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