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MilliporeSigma™ Calbiochem™ Akt Inhibitor XIV

The Akt Inhibitor XIV, also referenced under CAS 1191951-57-1, controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Manufacturer:  MilliporeSigma™ 12403210MG

Catalog No. 12-403-210MG


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Description

Description

A cell-permeable thiadiazolyl compound that binds to PH (pleckstrin homology) domain (Kd = 40.8μM, Ki = 2.4μM) and acts as a competitive and reversible blocker of Akt translocation to the cellular membrane with selectivity over PDK1 (Kd = 90.1μM, Ki = 5.5μM). Inhibits pAkt-Ser473 (IC50 = 6.3, 8.6 and 10μM in Panc-1, BxPC-3 and MiaPaCa-2 cells, respectively), and induces apoptosis at 20μM (40% and 31%) and causes growth arrest (IC50 = 65 and 30μM) in Panc-1 and MiaPaCa-2 cells, respectively. Further, suppresses tumor growth and regression in mouse xenograft model (125mg/kg, i.p.) and reduces pGSK-3α-Ser21 and pGSK-3β-Ser9 and p70S6K-Thr389/SUP> levels.
Specifications

Specifications

95% by HPLC
10mg
C20H31N3O2S2
DMSO
White solid
1191951-57-1
409.6g/mol
SDS
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