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MilliporeSigma™ Calbiochem™ Akt Inhibitor XV, Isozyme-Selective

The Akt Inhibitor XV, Isozyme-Selective controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Manufacturer:  MilliporeSigma™ 1240342MG

Catalog No. 12-403-42MG


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Description

Description

A cell-permeable naphthyridinone compound that acts as an allosteric Akt1/2-selective inhibitor (IC50 = 3.5, 42, and 1900nM against Akt1, Akt2, and Akt3, respectively) in a PH domain-dependent, but not ATP-competitive, manner, with little activity against a panel of more than 160 other kinases, including the related AGC family kinases (inactive at 10μM against GSK, PDK1, PKA, PKC, and SGK). Effectively inhibits the basal Akt phosphorylation in cancer cells with deregulated Akt pathway activation, including the HCT116 colorectal carcinoma and a panel of breast cancer cell lines (IC50 <500 nM), and suppresses Akt-dependent cell growth both in cultures in vitro (IC50 ≤1μM) and in mice in vivo (50 to 100mg/kg, SC). Although also referred to as AKTi-1/2, this is not the same compound as Akt Inhibitor XV (Cat. Nos. 124017 & 124018).
Specifications

Specifications

97% by HPLC
2mg
539.6g/mol
White powder
C33H29N7O
DMSO
SDS
Documents
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